Current state on development of neuroprotective agents for cerebral ischemia

Neuroprotective Consequences of Postconditioning on Embolic Model of Cerebral Ischemia in Rat

Neuroprotective effects of Withania coagulans root extract on CA1 hippocampus following cerebral ischemia in rats

Objective: Oxygen free radicals may be implicated in the pathogenesis of ischemia reperfusion damage. The beneficial effects of antioxidant nutrients, as well as complex plant extracts, on cerebral ischemia-reperfusion injuries are well known. This study was conducted to determine the effects of the hydro-alcoholic root extract of Withania coagulans on CA1 hippocampus oxidative damages followin...

Neuroprotective role of erythropoietin in cerebral ischemia

Studies show that erythropoietin, besides its critical role in hematopoiesis, provides neuroprotection in hypoxic-ischemic cerebral injury. Antiapoptotic, anti-inflammatory, angiogenetic, and neurotrophic properties of erythropoietin could increase indications, currently restricted to anemia in chronic renal failure and cancer, to hypoxic-ischemic cerebral insult. In the adult and neonatal anim...

Neuroprotective role of lactate after cerebral ischemia.

It is well established that lactate can be used as an energy substrate by the brain by conversion to pyruvate and a subsequent oxidation in the mitochondria. Knowing the need for readily metabolizable substrates directly after ischemia and the protective effect of lactate after excitotoxicity, the aim of this study was to investigate whether lactate administration directly after ischemia could ...

Neuroprotective effects of NKN on focal cerebral ischemia in rats.

AIM NKN reduces brain edema, neuronal death and neurological deficits in rats after cerebral ischemia. In the present study, we investigated whether NKN was effective on brain injury in cerebral ischemia rats. MATERIAL AND METHODS The middle cerebral artery occlusion (MCAO) model was used to produce experimental cerebral ischemia in adult male Wistar rats. The activity of SOD ...